Publications

Select Publications

Posttranslational Modifications in Oocyte Development

Liao Z, Steenwinkel TE, Moscoso B, Salas E, Patton BK, Rodriguez A, Malovannaya A, Pangas SA. Disruption of oocyte SUMOylation impacts critical regulatory processes during folliculogenesis in mice. Biol Reprod. 2025 May 13;112(5):932-941. doi: 10.1093/biolre/ioaf035. PMID: 39982420.

Briley, S.M., Ahmed, A.A., Steenwinkel, T.E., Jiang, P., Hartig, S.M., Schindler, K., and S.A. Pangas (2023). Global SUMOylation in mouse oocytes maintains oocyte identify and regulates chromatin remodeling and trancriptional silencing at the end of folliculogenesis. Development 150: dev201535. doi: 10.1242/dev.201535

Patton, B., Madadi, S., Briley, S.M., Ahmed, A.A., and S.A. Pangas (2023) Sumoylation regulates functional properties of the oocyte transcription factors, Sohlh1 and Nobox. Faseb J. 37:e22747. doi: 10.1096/fj.202201481R

Rodriguez A, Briley SM, Patton BK, et al. Loss of the E2 SUMO-conjugating enzyme Ube2i in oocytes during ovarian folliculogenesis causes infertility in mice. Development. 2019;146(23). PMCID: PMC6918767.

TGFB Family & Reproductive Function

Rydze RT, Patton BK, Briley SM, Salazar Torralba H, Gipson G, James R, Rajkovic A, Thompson T, Pangas SA. Deletion of Gremlin-2 alters estrous cyclicity and disrupts female fertility in mice. Biol. Reprod. 2021;105(1205). PMCID: PMC8599072

Rodriguez A, Tripurani SK, Burton JC, Clementi C, Larina I, Pangas SA. SMAD Signaling Is Required for Structural Integrity of the Female Reproductive Tract and Uterine Function During Early Pregnancy in Mice. Biol Reprod. 2016;95(2):44. PMCID: PMC5029477.

Myers M, Mansouri-Attia N, James R, Peng J, Pangas SA. GDF9 modulates the reproductive and tumor phenotype of female inha-null mice. Biol Reprod. 2013;88(4):86. PMCID: PMC4013870.

Myers M, Tripurani SK, Middlebrook B, Economides AN, Canalis E, Pangas SA. Loss of gremlin delays primordial follicle assembly but does not affect female fertility in mice. Biol Reprod. 2011;85(6):1175-82. PMCID: PMC3223251.

Pangas SA, Li X, Umans L, Zwijsen A, Huylebroeck D, Gutierrez C, et al. Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice. Mol Cell Biol. 2008;28(1):248-57. PMCID: PMC2223289.

Pangas SA, Jorgez CJ, Matzuk MM. Growth differentiation factor 9 regulates expression of the bone morphogenetic protein antagonist gremlin. J Biol Chem. 2004;279(31):32281-6.

McKenzie LJ, Pangas SA, Carson SA, Kovanci E, Cisneros P, Buster JE, et al. Human cumulus granulosa cell gene expression: a predictor of fertilization and embryo selection in women undergoing IVF. Hum Reprod. 2004;19(12):2869-74.

Adipose & Fertility

Anaya ES, Dion W, Saha PK, Cox AR, de Groot E, Ahmed AA, Felix JB, Zhu B, Pangas SA, Hartig SM. A Mouse Model of Lipoatrophy Reveals Relationships Between Beige Fat Appearance and Female Fertility. Endocrinology. 2025 Dec 5;167(1):bqaf164. doi: 10.1210/endocr/bqaf164. PMID: 41206127; PMCID: PMC12686663.

Anaya ES, de Groot EL, Lydon JP, Pangas SA, Hartig SM. Contributions of white adipose tissue to energy requirements for female reproduction. Trends Endocrinol Metab. 2024 Sep;35(9):809-820. doi: 10.1016/j.tem.2024.04.012. Epub 2024 May 14. PMID: 38749883; PMCID: PMC11387141.

Cox AR, Chernis N, Kim KH, Masschelin PM, Saha PK, Briley SM, Sharp R, Li X, Felix JB, Sun Z, Moore DD, Pangas SA, Hartig SM. Ube2i deletion in adipocytes causes lipoatrophy in mice. Mol. Metab. 2021. 48:101221. PMCID: PMC8080079

Granulosa Cell Tumors

Mansouri-Attia N, Tripurani SK, Gokul N, Piard H, Anderson ML, Eldin K, et al. TGFbeta signaling promotes juvenile granulosa cell tumorigenesis by suppressing apoptosis. Mol Endocrinol. 2014;28(11):1887-98. PMCID: PMC4213364.

Mansouri-Attia N, James R, Ligon A, Li X, Pangas SA. Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line. Biol Reprod. 2014;91(4):100. PMCID: PMC4435027.

Tripurani SK, Cook RW, Eldin KW, Pangas SA. BMP-specific SMADs function as novel repressors of PDGFA and modulate its expression in ovarian granulosa cells and tumors. Oncogene. 2013;32(33):3877-85. PMCID: PMC3525720.

Middlebrook BS, Eldin K, Li X, Shivasankaran S, Pangas SA. Smad1-Smad5 ovarian conditional knockout mice develop a disease profile similar to the juvenile form of human granulosa cell tumors. Endocrinology. 2009;150(12):5208-17. PMCID: PMC2819741.

Oocyte Transcription Factors

Pangas SA, Choi Y, Ballow DJ, Zhao Y, Westphal H, Matzuk MM, et al. Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Proc Natl Acad Sci U S A. 2006;103(21):8090-5. PMCID: PMC1472434.

Ballow DJ, Xin Y, Choi Y, Pangas SA, Rajkovic A. Sohlh2 is a germ cell-specific bHLH transcription factor. Gene Expr Patterns. 2006;6(8):1014-8.

Rajkovic A, Pangas SA, Ballow D, Suzumori N, Matzuk MM. NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Science. 2004;305(5687):1157-9.

Pangas SA, Yan W, Matzuk MM, Rajkovic A. Restricted germ cell expression of a gene encoding a novel mammalian HORMA domain-containing protein. Gene Expr Patterns. 2004;5(2):257-63.

Commentaries

Ahmed AA, Pangas SA. The aging ovary stands on the shoulders of giant multinucleated cells. PLoS Biol. 2025 Jun 24;23(6):e3003216. doi: 10.1371/journal.pbio.3003216. PMID: 40554744; PMCID: PMC12187170.

Steenwinkel TE, Pangas SA. Myostatin’s flex on the reproductive hormone axis. Science. 2025 Jan 17;387(6731):249-250. doi: 10.1126/science.adu7735. Epub 2025 Jan 16. PMID: 39818887.