Peer Reviewed Publications

Briley, S.M., Ahmed, A.A., Jiang, P., Hartig, S.M., Schindler, K., and S.A. Pangas. The E2 SUMO-conjugating enzyme UBE2I coordinates the oocyte and zygotic transcriptional programs, in review. Preprint available at

Patton, B., Madadi, S., Briley, S.M., Ahmed, A.A., and S.A. Pangas (2023) Sumoylation regulates functional properties of the oocyte transcription factors, Sohlh1 and Nobox. Faseb J. 37:e22747. doi: 10.1096/fj.202201481R

Patton BK, Madadi S, and Pangas SA Control of Ovarian Follicle Development by TGFB family signaling. Curr Opin Endocr Metab Res. 2021; 18(102). PMCID: PMC8535782

Rydze RT, Patton BK, Briley SM, Salazar Torralba H, Gipson G, James R, Rajkovic A, Thompson T, Pangas SA. Deletion of Gremlin-2 alters estrous cyclicity and disrupts female fertility in mice. Biol. Reprod. 2021;105(1205). PMCID: PMC8599072

Cox AR, Chernis N, Kim KH, Masschelin PM, Saha PK, Briley SM, Sharp R, Li X, Felix JB, Sun Z, Moore DD, Pangas SA, Hartig SM. Ube2i deletion in adipocytes causes lipoatrophy in mice. Mol. Metab. 2021. 48:101221. PMCID: PMC8080079

Rodriguez A, Briley SM, Patton BK, et al. Loss of the E2 SUMO-conjugating enzyme Ube2i in oocytes during ovarian folliculogenesis causes infertility in mice. Development. 2019;146(23). PMCID: PMC6918767.

Chen H, Crosley P, Azad AK, Gupta N, Gokul N, Xu Z, et al. RUNX3 Promotes the Tumorigenic Phenotype in KGN, a Human Granulosa Cell Tumor-Derived Cell Line. Int J Mol Sci. 2019;20(14). PMCID: PMC6678151.

Wu H, Pangas SA, Eldin KW, Patel KR, Hicks J, Dietrich JE, et al. Juvenile Granulosa Cell Tumor of the Ovary: A Clinicopathologic Study. J Pediatr Adolesc Gynecol. 2017;30(1):138-43.

Monsivais D, Matzuk MM, Pangas SA. The TGF-beta Family in the Reproductive Tract. Cold Spring Harb Perspect Biol. 2017;9(10). PMCID: PMC5554737.

Rodriguez A, Tripurani SK, Burton JC, Clementi C, Larina I, Pangas SA. SMAD Signaling Is Required for Structural Integrity of the Female Reproductive Tract and Uterine Function During Early Pregnancy in Mice. Biol Reprod. 2016;95(2):44. PMCID: PMC5029477.

Rodriguez A, Pangas SA. Regulation of germ cell function by SUMOylation. Cell Tissue Res. 2016;363(1):47-55. PMCID: PMC4703547.

Peng J, Monsivais D, You R, Zhong H, Pangas SA, Matzuk MM. Uterine activin receptor-like kinase 5 is crucial for blastocyst implantation and placental development. Proc Natl Acad Sci U S A. 2015;112(36):E5098-107. PMCID: PMC4568667.

Liu Z, Ren YA, Pangas SA, Adams J, Zhou W, Castrillon DH, et al. FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development. Mol Endocrinol. 2015;29(7):1006-24. PMCID: PMC4484779.

Mansouri-Attia N, Tripurani SK, Gokul N, Piard H, Anderson ML, Eldin K, et al. TGFbeta signaling promotes juvenile granulosa cell tumorigenesis by suppressing apoptosis. Mol Endocrinol. 2014;28(11):1887-98. PMCID: PMC4213364.

Mansouri-Attia N, James R, Ligon A, Li X, Pangas SA. Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line. Biol Reprod. 2014;91(4):100. PMCID: PMC4435027.

Tripurani SK, Cook RW, Eldin KW, Pangas SA. BMP-specific SMADs function as novel repressors of PDGFA and modulate its expression in ovarian granulosa cells and tumors. Oncogene. 2013;32(33):3877-85. PMCID: PMC3525720.

Myers M, Mansouri-Attia N, James R, Peng J, Pangas SA. GDF9 modulates the reproductive and tumor phenotype of female inha-null mice. Biol Reprod. 2013;88(4):86. PMCID: PMC4013870.

Clementi C, Tripurani SK, Large MJ, Edson MA, Creighton CJ, Hawkins SM, et al. Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans. PLoS Genet. 2013;9(11):e1003863. PMCID: PMC3828128.

Szigeti R, Pangas SA, Nagy-Szakal D, Dowd SE, Shulman RJ, Olive AP, et al. SMAD4 haploinsufficiency associates with augmented colonic inflammation in select humans and mice. Ann Clin Lab Sci. 2012;42(4):401-8. PMCID: PMC3875295.

Pangas SA. Bone morphogenetic protein signaling transcription factor (SMAD) function in granulosa cells. Mol Cell Endocrinol. 2012;356(1-2):40-7. PMCID: PMC3203253.

Pangas SA. Regulation of the ovarian reserve by members of the transforming growth factor beta family. Mol Reprod Dev. 2012;79(10):666-79. PMCID: PMC3473177.

Li X, Tripurani SK, James R, Pangas SA. Minimal fertility defects in mice deficient in oocyte-expressed Smad4. Biol Reprod. 2012;86(1):1-6.

Myers M, Tripurani SK, Middlebrook B, Economides AN, Canalis E, Pangas SA. Loss of gremlin delays primordial follicle assembly but does not affect female fertility in mice. Biol Reprod. 2011;85(6):1175-82. PMCID: PMC3223251.

Richards JS, Pangas SA. The ovary: basic biology and clinical implications. J Clin Invest. 2010;120(4):963-72. PMCID: PMC2846061.

Richards JS, Pangas SA. New insights into ovarian function. Handb Exp Pharmacol. 2010(198):3-27. PMCID: PMC4551424.

Nagaraja AK, Middlebrook BS, Rajanahally S, Myers M, Li Q, Matzuk MM, et al. Defective gonadotropin-dependent ovarian folliculogenesis and granulosa cell gene expression in inhibin-deficient mice. Endocrinology. 2010;151(10):4994-5006. PMCID: PMC2946151.

Myers M, Pangas SA. Regulatory roles of transforming growth factor beta family members in folliculogenesis. Wiley Interdiscip Rev Syst Biol Med. 2010;2(1):117-25.

Edson MA, Nalam RL, Clementi C, Franco HL, Demayo FJ, Lyons KM, et al. Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development. Mol Endocrinol. 2010;24(6):1251-66. PMCID: PMC2875809.

Myers M, Middlebrook BS, Matzuk MM, Pangas SA. Loss of inhibin alpha uncouples oocyte-granulosa cell dynamics and disrupts postnatal folliculogenesis. Dev Biol. 2009;334(2):458-67. PMCID: PMC2753717.

Middlebrook BS, Eldin K, Li X, Shivasankaran S, Pangas SA. Smad1-Smad5 ovarian conditional knockout mice develop a disease profile similar to the juvenile form of human granulosa cell tumors. Endocrinology. 2009;150(12):5208-17. PMCID: PMC2819741.

Su YQ, Sugiura K, Wigglesworth K, O’Brien MJ, Affourtit JP, Pangas SA, et al. Oocyte regulation of metabolic cooperativity between mouse cumulus cells and oocytes: BMP15 and GDF9 control cholesterol biosynthesis in cumulus cells. Development. 2008;135(1):111-21.

Pangas SA, Li X, Umans L, Zwijsen A, Huylebroeck D, Gutierrez C, et al. Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice. Mol Cell Biol. 2008;28(1):248-57. PMCID: PMC2223289.

Li Q, Pangas SA, Jorgez CJ, Graff JM, Weinstein M, Matzuk MM. Redundant roles of SMAD2 and SMAD3 in ovarian granulosa cells in vivo. Mol Cell Biol. 2008;28(23):7001-11. PMCID: PMC2593383.

Suzumori N, Pangas SA, Rajkovic A. Candidate genes for premature ovarian failure. Curr Med Chem. 2007;14(3):353-7.

Sugiura K, Su YQ, Diaz FJ, Pangas SA, Sharma S, Wigglesworth K, et al. Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells. Development. 2007;134(14):2593-603.

Pangas SA, Jorgez CJ, Tran M, Agno J, Li X, Brown CW, et al. Intraovarian activins are required for female fertility. Mol Endocrinol. 2007;21(10):2458-71.

Pangas SA. Growth factors in ovarian development. Semin Reprod Med. 2007;25(4):225-34.

Pangas SA, Rajkovic A. Transcriptional regulation of early oogenesis: in search of masters. Hum Reprod Update. 2006;12(1):65-76.

Pangas SA, Li X, Robertson EJ, Matzuk MM. Premature luteinization and cumulus cell defects in ovarian-specific Smad4 knockout mice. Mol Endocrinol. 2006;20(6):1406-22.

Pangas SA, Choi Y, Ballow DJ, Zhao Y, Westphal H, Matzuk MM, et al. Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Proc Natl Acad Sci U S A. 2006;103(21):8090-5. PMCID: PMC1472434.

Ballow DJ, Xin Y, Choi Y, Pangas SA, Rajkovic A. Sohlh2 is a germ cell-specific bHLH transcription factor. Gene Expr Patterns. 2006;6(8):1014-8.

Yan W, Ma L, Stein P, Pangas SA, Burns KH, Bai Y, et al. Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility. Mol Cell Biol. 2005;25(11):4615-24. PMCID: PMC1140637.

Pangas SA, Matzuk MM. The art and artifact of GDF9 activity: cumulus expansion and the cumulus expansion-enabling factor. Biol Reprod. 2005;73(4):582-5.

Rajkovic A, Pangas SA, Ballow D, Suzumori N, Matzuk MM. NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Science. 2004;305(5687):1157-9.

Pangas SA, Yan W, Matzuk MM, Rajkovic A. Restricted germ cell expression of a gene encoding a novel mammalian HORMA domain-containing protein. Gene Expr Patterns. 2004;5(2):257-63.

Pangas SA, Matzuk MM. Genetic models for transforming growth factor beta superfamily signaling in ovarian follicle development. Mol Cell Endocrinol. 2004;225(1-2):83-91.

Pangas SA, Jorgez CJ, Matzuk MM. Growth differentiation factor 9 regulates expression of the bone morphogenetic protein antagonist gremlin. J Biol Chem. 2004;279(31):32281-6.

McKenzie LJ, Pangas SA, Carson SA, Kovanci E, Cisneros P, Buster JE, et al. Human cumulus granulosa cell gene expression: a predictor of fertilization and embryo selection in women undergoing IVF. Hum Reprod. 2004;19(12):2869-74.

Pangas SA, Saudye H, Shea LD, Woodruff TK. Novel approach for the three-dimensional culture of granulosa cell-oocyte complexes. Tissue Eng. 2003;9(5):1013-21.

Pangas SA, Woodruff TK. Production and purification of recombinant human inhibin and activin. J Endocrinol. 2002;172(1):199-210.

Pangas SA, Rademaker AW, Fishman DA, Woodruff TK. Localization of the activin signal transduction components in normal human ovarian follicles: implications for autocrine and paracrine signaling in the ovary. J Clin Endocrinol Metab. 2002;87(6):2644-57.

Pangas SA, Woodruff TK. Activin signal transduction pathways. Trends Endocrinol Metab. 2000;11(8):309-14.

Chong H, Pangas SA, Bernard DJ, Wang E, Gitch J, Chen W, et al. Structure and expression of a membrane component of the inhibin receptor system. Endocrinology. 2000;141(7):2600-7.

Book Chapters

Rodriguez, A., Rydze, R.T., Briley, S., and S.A. Pangas (2018). Chapter 18: Transgenic mouse models in the study of ovarian function, In: The Ovary, 3rd Edition, Leung, P.C.K., and Adashi, E.Y., Eds., (Elsevier), pp. 295-310

Rodriguez, A., Matzuk, M.M., and S.A. Pangas (2018). Chapter 6: Growth factors and Reproduction. In: Yen and Jaffe’s Reproduction, 8th Edition, Strauss, J. and R. Barbieri, Eds. (Elsevier Press), pp 132-148.

Monsivais, D., Matzuk, M.M., and S.A. Pangas (2017). The TGFb family in the Reproductive Tract: Development and Function. In: TGFb, R. Derynck and K. Miyazono, Eds., 2nd Edition (Cold Spring Harbor Press)

Pangas, S.A. and A. Rajkovic (2013). Mammalian models for follicular development. In: The Physiology of Reproduction, J.D. Neill, Ed. 4rd Edition (Elsevier Press).

Clementi, C., Pangas, S.A., and M.M. Matzuk (2013). Growth factors and reproduction. In: Yen and Jaffe’s Reproduction, 7th Edition, Strauss, J. and R. Barbieri, Eds. (Elsevier Press).

Tripurani, S.K. and S.A. Pangas (2012). Regulation of oogenesis by oocyte-specific networks. In: Mammalian Oogenesis, G. Coticchio, L. DeSantis, and D. Albertini, Eds. (Springer Press), pp. 129-140.

Richards, J.S and S.A. Pangas (2010). New insights into ovarian function. In: Handbook of Experimental Pharmacology – Contraception. U.-F. Habenicht and J. Aitken, Eds. (Springer Press), pp. 3-27

Pangas, S.A and M.M. Matzuk (2007). The TGFb family in the Reproductive Tract. In: TGFb, R Derynck and K. Miyazono, Eds., 1st Edition (Cold Spring Harbor Press), pp. 861-888.

Rajkovic, A., Pangas, S.A., and M.M. Matzuk (2006). Follicular development: mouse, sheep and human models. In: The Physiology of Reproduction, J.D. Neill, Ed. 3rd Edition (Elsevier Press), pp. 383-423.